A vision of the far future might include humanity living on colonies on various moons, as well as in solar-orbiting habitats. These human colonies will need raw materials, including water, metals, and stock minerals and materials for soil to grow crops. Materials for various manufacturing needs, especially for fabricating large structures, will be needed. Asteroids rich in certain materials will likely become rare and precious, as more and more are sought out and used up.
It is not so hard to visualize a time when humanity must search ever outward, to the edges of the Solar system and beyond, in the ceaseless hunt for more raw materials to support human habitation. While the Kiuper belt will keep us busy for quite a while, it could conceivably become exhausted of certain ores and such in high demand – especially water ice.
Looking further in the future, it is not such a stretch that humanity will head ever farther out in search of raw materials. Perhaps all the way to neighboring star systems. And just perhaps, humanity is not alone in such a need for raw materials. Other civilizations might experience similar needs!
So if large moons or objects begin disappearing at the edge of our own Solar System, we may have an explanation of why. Every intelligent civilization/race needs room to grow, and raw materials to eat and consume.
I just hope we get out there first, before THEY do.